5'-chloro-5'-deoxy-(±)-ENBA

**5'-chloro-5'-deoxy-(±)-ENBA** is a highly selective small-molecule agonist of the adenosine A1 receptor, with pronounced selectivity over other adenosine receptor subtypes (Ki, human, nM: A1 = 0.51; A2A = 1340; A2B = 2740; A3 = 1290). Preclinical studies demonstrated **potent antinociceptive** (analgesic) properties: it reduces mechanical allodynia and thermal hyperalgesia in mouse models of neuropathic pain, apparently via centrally mediated activation of A1 receptors, including effects on spinal cord astrocytes and microglia. Notably, at analgesic doses it does not significantly affect motor coordination, blood pressure, or heart rate, which are major limitations for nonselective adenosine receptor agonists. The compound is used as a pharmacological tool for adenosine A1 receptor research and as an experimental analgesic in preclinical studies[1][3][5].

Other names

N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine(2R,3R,4S,5S)-2-(6-((1R,2R,4R)-bicyclo[2.2.1]heptan-2-ylamino)-9H-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol