5'-Fluoro-5'-Deoxyadenosine

**5'-Fluoro-5'-Deoxyadenosine** is a synthetic fluorinated nucleoside analog of adenosine, in which the hydroxyl group at the 5' position of the ribose ring is replaced by a fluorine atom. This modification increases its resistance to enzymatic degradation and alters its biochemical properties. It is not an approved pharmaceutical drug but is widely used as a research tool in studies of nucleoside metabolism, enzyme mechanisms, and biosynthesis of organofluorines. In nature, it is produced by certain bacteria (e.g., Streptomyces cattleya) via fluorinase-catalyzed reaction between S‑adenosyl-L-methionine (SAM) and fluoride ion, releasing L-methionine as a byproduct[1][4][9]. The compound has been investigated for potential antiviral and anticancer activities due to its ability to interfere with nucleic acid metabolism[4][5]. Its main mechanism involves acting as an analog or substrate mimic in enzymatic reactions related to nucleotide processing.

Other names

5′-Deoxy-5′-fluoroadenosineAdenosine, 5′‑deoxy‑5′‑fluoro-Deoxy‑5'‑fluoroadenosine