Drug intelligence / Profile preview

5'-Guanosine-Diphosphate-Monothiophosphate

Development stage: Unknown
Modality: Small Molecules

Overview

**5'-Guanosine-Diphosphate-Monothiophosphate** is a stable analog of guanosine triphosphate (GTP) in which one of the nonbridging oxygen atoms at the γ-phosphate position is replaced by sulfur. This modification makes it resistant to hydrolysis by GTPases, allowing it to act as a tool compound in biochemical research. It stimulates guanine nucleotide-binding proteins (G-proteins), promotes phosphoinositide hydrolysis, increases cyclic AMP accumulation, and can activate specific proto-oncogenes. Its primary use is experimental, particularly for studying signal transduction pathways involving G-proteins and related enzymes[2].

Other names: Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid

Targets

Gα (G-protein α subunits)

Beyond the preview

Go deeper on 5'-Guanosine-Diphosphate-Monothiophosphate.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 5'-Guanosine-Diphosphate-Monothiophosphate.

Explore the full profile