5'-O-[(L-methionyl)-sulphamoyl]adenosine

5'-O-[(L-methionyl)-sulphamoyl]adenosine is a synthetic small molecule that acts as an analogue of aminoacyl-adenosine monophosphate. It is primarily studied as an experimental inhibitor of aminoacyl-tRNA synthetases, particularly methionine--tRNA ligase, which are enzymes essential for protein synthesis. The compound features a methionyl group linked to adenosine via a stable sulfamoyl bond, enhancing its binding affinity and inhibitory properties compared to natural substrates. By mimicking the natural substrate's interactions within the catalytic pocket of aminoacyl-tRNA synthetases, it competitively inhibits these enzymes and disrupts normal protein synthesis pathways. This mechanism makes it valuable in biochemical research and as a potential lead compound for developing new antibacterial agents targeting translational control[1][2][4].

Other names

5'-O-[(L-Methionyl)-Sulphamoyl]AdenosineDB02229DB-02229DB 02229