5'tRF-GlyGCC mimic

5'tRF-GlyGCC mimic is a synthetic RNA oligonucleotide designed to replicate the functional activity of the endogenous 5' transfer RNA-derived fragment (tRF) generated from tRNA-Gly-GCC. In breast cancer, this specific tRF is overexpressed and functions as an oncogenic driver. The mimic acts by binding to lactate dehydrogenase A (LDHA), particularly when LDHA is phosphorylated at tyrosine 10 by fibroblast growth factor receptor 1 (FGFR1). This binding enhances the enzymatic activity of LDHA, thereby promoting aerobic glycolysis and metabolic reprogramming that supports tumor cell malignancy. Additionally, the 5'tRF-GlyGCC/LDHA axis induces the secretion of the chemokine CCL7, which facilitates macrophage infiltration and polarization toward a pro-tumorigenic M2 phenotype. While the mimic is primarily used in research to characterize these oncogenic pathways, the axis it targets is being investigated for therapeutic intervention in breast cancer.

Other names

5'-tRF-Gly-GCC mimictRF-Gly-GCC mimictRNA-derived fragment Gly-GCC mimic