5,8-di-amino-1,4-dihydroxy-anthraquinone

**5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone** is a synthetic anthraquinone derivative with the molecular formula C14H10N2O4 and a molecular weight of approximately 270.24. It features amino groups at positions 5 and 8 and hydroxyl groups at positions 1 and 4 on the anthraquinone core. This compound is structurally related to other anthracenediones used in cancer therapy. The primary mechanism of action involves inhibition of casein kinase II subunit alpha (CSNK2A1), a protein kinase implicated in various cellular processes including cell cycle regulation and apoptosis[3][1][4]. The compound’s planar aromatic structure allows for DNA intercalation—a property associated with antitumor activity in preclinical models[3]. Its dihydrochloride salt (CL232315; NSC301739D) has shown significant efficacy in murine leukemia and solid tumor models but has not advanced to clinical use. Currently classified as an experimental small molecule drug candidate with no approved indications or ongoing clinical trials[1], it remains primarily a research tool for studying kinase inhibition and DNA-interactive chemotypes within oncology research.

Other names

1,4-diamino-5,8-dihydroxyanthraquinone1,4-diamino-5,8-dihydroxy-9,10-anthracenedione9,10-anthracenedione, 1,4-diamino-5,8-dihydroxy-DAAMNY