5'-Deoxy-5'-(Methylthio)-Tubercidin

**5'-Deoxy-5'-(Methylthio)-Tubercidin** is a synthetic small molecule analog of tubercidin. It features a methylthio group at the 5’ position of the ribose moiety. This compound acts as an inhibitor of enzymes involved in nucleoside metabolism—specifically targeting enzymes such as methylthioadenosine phosphorylase and nucleosidases. It has been used primarily as a biochemical tool to study enzyme specificity and kinetics in purine metabolism pathways and is not approved for therapeutic use. Its mechanism involves competitive inhibition at the active site of these enzymes by mimicking natural substrates[2][8]. The compound is mainly used in research settings.

Other names

5'-Deoxy-5'-(methylthio)-tubercidin7-(5-S-methyl-5-thio-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(2R,3R,4S,5S)-2-{4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(methylsulfanyl)methyloxolane-3,4-diol61893–98–9MTH (PDB code)