5'-O-(L-Prolylsulfamoyl)adenosine

5'-O-(L-Prolylsulfamoyl)adenosine is a synthetic small molecule and a purine nucleoside analog. It is structurally related to adenosine but features a prolylsulfamoyl group at the 5' position of the ribose moiety. This compound acts as a stable analog of the aminoacyl adenylate intermediate formed during tRNA aminoacylation by aminoacyl-tRNA synthetases. Specifically, it mimics the prolyl-AMP intermediate and serves as a potent inhibitor of prolyl-tRNA synthetase (ProRS), an enzyme essential for protein synthesis in cells[1][6][9]. Its primary use has been in biochemical and structural studies to investigate enzyme mechanisms rather than as an approved therapeutic agent.

Other names

5′-O-(N-(L-prolyl)-sulfamoyl)adenosine5′-O-[N-(L-prolyl)-sulfamoyl]-adenosineP5AP-5AP 5A