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5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide

Development stage
Preclinical
Modality
Small Molecules
01

Overview

5-(5-chloro-2,4-dihydroxyphenyl)-N‑ethyl‑4‑(4‑methoxyphenyl)‑1H‑pyrazole‑3-carboxamide is a synthetic small molecule that acts as an inhibitor of heat shock protein 90 (Hsp90). It belongs to the class of phenylpyrazoles and resorcinol derivatives. Hsp90 is a molecular chaperone involved in the folding and stabilization of many client proteins, including several oncogenic kinases. Inhibition of Hsp90 can disrupt multiple signaling pathways critical for cancer cell survival and proliferation. This compound has been studied primarily as a chemical probe or experimental agent in preclinical research settings[2][5].

Other names
558640-51-0940289-57-6CHEBI:47273SCHEMBL2684425SCHEMBL-2684425SCHEMBL 2684425SCHEMBL21067994SCHEMBL-21067994SCHEMBL 21067994
02

Targets

HSP90AA1 (Heat shock protein HSP90-alpha)

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