5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

This compound is a small molecule experimental drug with molecular formula C24H26N4O and molecular weight approximately 386.49 g/mol. It is structurally characterized by a biphenyl moiety substituted with methoxy and dimethyl groups linked via a butynyl chain to a methyl-substituted pyrimidine diamine core. The drug acts as an inhibitor targeting dihydrofolate reductase (DHFR), specifically studied in the context of Candida glabrata fungal infections where it selectively inhibits the fungal enzyme over human DHFR. This mechanism disrupts folate metabolism critical for DNA synthesis in fungi, making it an antifolate agent with potential antifungal activity. The compound was developed for probing hydrophobic pockets in DHFR to enhance selectivity and potency against resistant fungal strains[7][10]. No marketed brand names or approved indications are currently available; it remains experimental[2].

Other names

(R)-5-(3-(5-methoxy - 2',6'-dimethylbiphenyl - 3 - yl)but - 1 - ynyl) - 6 - methylpyrimidine - 2,4-diamine53V