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5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the biphenyl and pyrimidinediamine chemical classes. It is an experimental drug with no approved medical indications or clinical trial data available. The molecule has been studied as a propargyl-based inhibitor of dihydrofolate reductase (DHFR), an enzyme critical for DNA synthesis and cell proliferation. Inhibition of DHFR is a well-established anticancer strategy; thus, this compound has potential therapeutic applications in oncology as an anticancer agent[7][8]. However, there are no published results from clinical trials or regulatory approvals for this compound.
- Other names
- 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine5-{3-[3-methoxy-[1,1'-biphenyl]-3'-yl]butynyl}-6-methylpyrimidine 2,4-diaminepropargyl-based inhibitor R‑10a
02
Targets
DHFR (Dihydrofolate reductase)
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