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5-[(3S)-3-(2-methoxybiphenyl-4-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the class of biphenyl derivatives. It was developed as part of a series of propargyl-linked dihydrofolate reductase (DHFR) inhibitors designed to overcome resistance in methicillin-resistant Staphylococcus aureus (MRSA). The molecule specifically targets bacterial DHFR—including mutant forms that confer resistance to trimethoprim—by binding and inhibiting its enzymatic activity. This mechanism disrupts folate metabolism and DNA synthesis in bacteria. The compound has been studied experimentally for its antibacterial properties but is not approved for clinical use[8][9].
- Other names
- 5-[(3s)-3-(2-Methoxybiphenyl-4-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine5-[3S-(3-methoxy[1,1'-biphenyl]-4'-yl)butynyl]-6-methylpyrimidine 2,4-diamine
02
Targets
DHFR (Dihydrofolate reductase)
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