5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine

This compound is a synthetic small molecule belonging to the class of quinazoline derivatives and n-benzylpiperidines. It has been studied as an experimental drug candidate with potential biological activities including enzyme inhibition. Notably, it acts as a potent inhibitor of m7GpppX diphosphatase (also known as scavenger decapping enzyme DcpS), with nanomolar affinity. It also shows weak inhibitory activity against cytochrome P450 2D6 and dihydrofolate reductase in vitro. The compound has not been approved for any therapeutic use and is primarily used in research settings to study RNA metabolism and related cellular processes. No clinical trials or approved indications are reported for this molecule.

Other names

5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine5-{[1-(2-Fluorbenzyl)-4-piperidinyl]methoxy}-2,4-chinazolindiamin5-{[1-(2-Fluorobenzyl)-4-piperidinyl]methoxy}-2,4-quinazolinediamine5-{[1-(2-Fluorobenzyl)-4-pipéridinyl]méthoxy}-2,4-quinazolinediamine (French)5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline‑2,4‑diamine (IUPAC)