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5-amino-2-(4-bromophenyl)benzoxazole
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
5-amino-2-(4-bromophenyl)benzoxazole is a small molecule research compound belonging to the 2,5-disubstituted benzoxazole class of fused heterocyclic compounds. It has been studied in academic research as a DNA topoisomerase I inhibitor, demonstrating greater potency than the reference drug camptothecin in cell-free eukaryotic systems. Additionally, it has been investigated for its cytotoxic and antiapoptotic activities in breast cancer cell lines (such as MCF-7 and MDA-MB), where it has been shown to reduce VEGF activation, downregulate NF-κB and caspase-3 levels, and increase eNOS, Cytochrome C, and DNA damage (TUNEL). No formal clinical development program or commercial developer has been identified for this compound.
- Other names
- 5-amino-2-(p-bromophenyl)-benzoxazole5-amino-2-(p-bromophenyl)benzoxazole
02
Targets
TOP2A (DNA topoisomerase II)TOP1 (DNA Topoisomerase I)
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