5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide

**Mechanism of Action:** 5-Amino-2-methyl-N+[(1R)-1-naphthalen+ylethyl]benzamide (GRL0617) is a synthetic small molecule inhibitor of the papain-like protease (PLpro) of SARS-CoV and SARS-CoV+ viruses. It selectively blocks viral PLpro activity, which is essential for viral replication and for suppressing host innate immune responses. By inhibiting PLpro, it prevents both viral polyprotein processing and antagonism of host antiviral defenses[6]. This compound has been investigated as a potential antiviral agent against coronaviruses.

Other names

5-amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)-benzamide5-amino-2-methyl-N-[((R)-1-(naphthalen-1-yl)ethyl)]benzamide(R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamideSCHEMBL3237378SCHEMBL-3237378SCHEMBL 3237378BCP33895BCP-33895BCP 33895AKOS015895833AKOS-015895833AKOS 015895833CHEBI:167176[3][4][6]