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5-aminolevulinic acid (Lee's Pharmaceutical Holdings Limited)
- Development stage
- Unknown
- Lead developer
- Lee's Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ZK041 is a development code for 5-aminolevulinic acid (5-ALA), a small molecule metabolic precursor used as an optical imaging agent for the intraoperative visualization of malignant gliomas. Developed by Lee's Pharmaceutical, ZK041 is administered orally prior to surgery. Once ingested, 5-ALA is preferentially metabolized by tumor cells into protoporphyrin IX (PpIX), a fluorescent compound, due to altered enzyme activity in the heme biosynthesis pathway of malignant cells. Under blue light excitation (wavelength 375–440 nm) during neurosurgery, the accumulated PpIX emits a red-violet fluorescence, allowing surgeons to distinguish between malignant tissue and healthy brain tissue. This fluorescence-guided surgery (FGS) technique is designed to improve the extent of tumor resection and potentially enhance patient outcomes.
- Brand names
- GleolanGliolan
- Other names
- 5-aminolevulinic acid5-ALAdelta-aminolevulinic acid5-aminolevulinic acid hydrochloride
02
Targets
Solute carrier family 15 member 1 (PEPT1), Solute carrier family 15 member 2 (PEPT2), and Solute carrier family 6 member 1 (GAT1)FECH (Ferrochelatase)Heme biosynthesis pathway enzymes
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