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5-carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid is an experimental small molecule belonging to the class of p-terphenyls. It is a brequinar-derived asymmetric terphenyl compound with the molecular formula C20H15NO3 and a molecular weight of approximately 317.34 g/mol[1][2][8]. The compound has been studied as an inhibitor of dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH), with reported enzyme inhibition activity in vitro (Ki = 2.8 µM)[2][5]. There are no approved indications or clinical trials beyond preclinical/biochemical studies, and it is not marketed as a pharmaceutical product[1].
- Other names
- 3-carbamoyl-5-(4-phenylphenyl)benzoic acid3-amido-5-biphenyl-benzoic acidCHEMBL203836CHEMBL-203836CHEMBL 203836
02
Targets
DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)
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