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5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclopentyl)thiophene-2-carboxamide
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclopentyl)thiophene-2-carboxamide is an experimental small molecule anticoagulant that acts as a potent and selective inhibitor of coagulation Factor Xa. It belongs to a series of enantiopure cis-cycloalkyldiamine derivatives developed for their neutral character and strong anticoagulant activity. The compound has been studied structurally in complex with Factor Xa to elucidate its binding mode and structure–activity relationships. It was developed by Bristol Myers Squibb as part of research into novel oral anticoagulants[3][4][5].
- Other names
- 5-chloro-N-[(1R,2S)-2-[4-(2-oxo-1,2-dihydropyridin-1-yl)benzamido]cyclopentyl]thiophene-2-carboxamide
02
Targets
F10 (Factor Xa)
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