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5-fluorouracil + adriamycin + cyclophosphamide + Iscador M special
- Development stage
- Preclinical
- Lead developer
- Iscador
- Modality
- Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
A combination chemotherapy regimen that includes three conventional chemotherapy agents (5-fluorouracil, adriamycin/doxorubicin, and cyclophosphamide) plus Iscador M special, which is a mistletoe extract preparation. The conventional components (FAC/CAF) are well-established for treating breast cancer. Each drug in this combination attacks cancer cells through different mechanisms: 5-fluorouracil stops cells from making and repairing DNA, adriamycin damages DNA and interferes with repair enzymes, and cyclophosphamide prevents cancer cell reproduction by cross-linking DNA strands.
- Other names
- FAC + Iscador M specialCAF + Iscador M special
02
Targets
DNATS (Thymidylate synthase)TOP2A (DNA topoisomerase II)
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