Drug intelligence / Profile preview

5-fluorouracil + cyclophosphamide + doxorubicin + methotrexate + prednisone + vinblastine + vincristine

Development stage
Unknown
Lead developer
Takeda
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Intravenous, Oral
01

Overview

This multi-drug chemotherapy regimen, consisting of 5-fluorouracil, cyclophosphamide, doxorubicin, methotrexate, prednisone, vinblastine, and vincristine, does not appear as a single established regimen in the search results. However, it comprises many drugs found in similar combination chemotherapy regimens such as CAF (cyclophosphamide, Adriamycin [doxorubicin], 5-fluorouracil) and CMFVP (cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone), which are used primarily in breast cancer treatment. These regimens are employed for various solid tumors. Response rates (e.g., 64% for CAF, 37% for CMFVP) and toxicity profiles (including nausea, vomiting, malaise, alopecia, granulocytopenia) vary between established combinations. Administration schedules are typically intermittent (e.g., 1 week out of 4) or according to other detailed protocols.

02

Targets

GR (Glucocorticoid receptor)TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)TUBB (Tubulin (alpha and beta subunits))

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