5-fluorouracil + cyclophosphamide + prednisolone

This is a combination chemotherapy regimen consisting of three drugs: - **5-fluorouracil** is an antimetabolite and pyrimidine analog that inhibits thymidylate synthase, disrupting DNA synthesis and function, leading to cell death. It is primarily used in the treatment of various solid tumors[5][7]. - **Cyclophosphamide** is an alkylating agent that crosslinks DNA strands, preventing cell division and resulting in cytotoxicity. It has both cytotoxic and immunosuppressive properties[6][8]. - **Prednisolone** is a synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive effects; it also induces apoptosis in certain cancer cells. The combination of these agents leverages their complementary mechanisms for enhanced antitumor activity. While regimens containing similar combinations (often with additional agents like methotrexate or vincristine) have been studied for various cancers such as breast cancer, solid tumors, lymphoma, and multiple myeloma[1][2][6][8], the specific triplet of 5-fluorouracil + cyclophosphamide + prednisolone may be considered investigational or off-label as a defined protocol.