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5-fluorouracil + petroleum jelly
- Development stage
- Unknown
- Lead developer
- Washington University School of Medicine
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
A topical combination of the antimetabolite 5-fluorouracil (5-FU) and petroleum jelly (Vaseline) used as a control arm in clinical trials conducted by Washington University School of Medicine. 5-fluorouracil is a pyrimidine analog that inhibits thymidylate synthase, thereby interfering with DNA synthesis and causing cell death in rapidly dividing cells like those in actinic keratosis. In this specific trial context, petroleum jelly serves as an inert vehicle replacing calcipotriol to evaluate the additive effect of calcipotriol when combined with the standard-of-care 5-FU. It is applied topically to treat actinic keratosis on the face, scalp, and extremities.
- Other names
- petroleum jelly-Washington University School of Medicine-actinic keratosis5-fluorouracil + Vaseline5-FU + petroleum jelly
02
Targets
Nucleotide synth (Nucleotide synthesis enzymes)
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