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Drug intelligence / Profile preview
5-fluorouracil + petroleum jelly
- Development stage
- Unknown
- Lead developer
- Massachusetts General Hospital
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
This topical combination formulation was developed by Massachusetts General Hospital (MGH) to serve as a control arm in clinical trials evaluating the efficacy of calcipotriol plus 5-fluorouracil (5-FU) for the treatment of actinic keratosis and the prevention of cutaneous squamous cell carcinoma. The preparation consists of 5% 5-fluorouracil cream mixed with petroleum jelly (Vaseline). In these randomized, double-blind trials, the petroleum jelly component acts as an inactive vehicle substitute for the active calcipotriol ointment used in the experimental arm, ensuring consistent application and blinding. While 5-fluorouracil is a potent antimetabolite that inhibits thymidylate synthase to disrupt DNA synthesis in proliferating tumor cells, the petroleum jelly itself is therapeutically inactive and serves primarily as an emollient vehicle.
- Other names
- Vaseline + 5-FU5-FU in petroleum jelly5% 5-fluorouracil cream mixed with petroleum jellyControl formulation (MGH AK/SCC trial)
02
Targets
TS (Thymidylate synthase)
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