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5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID is a synthetic small molecule identified as a carboxylate inhibitor of matrilysin (MMP-7), a member of the matrix metalloprotease family. Matrilysin plays a crucial role in the physiological and pathological degradation of the extracellular matrix, making it a target for various diseases, including cancer and arthritis. The compound's inhibitory action involves interaction with the catalytic zinc atom in the active site of matrilysin. This compound was characterized in the mid-1990s, with its structure complexed with matrilysin deposited in the Protein Data Bank (PDB ID: 1MMP) in 1995.
- Other names
- (3R)-5-methyl-3-[[(10S)-9-oxo-1,8-diazatricyclo[10.6.1.013,18]nonadeca-12(19),13,15,17-tetraen-10-yl]carbamoyl]hexanoic acid
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