5-quinoxalin-6-ylmethylene-thiazolidine-2,4-dione

5-quioxalin‑6‑ylmethylene‑thiazolidine‑2,4‑dione is a synthetic small molecule belonging to the quinoxaline and thiazolidinedione chemical classes. It acts as a potent and selective inhibitor of phosphatidylinositol 3‑kinase gamma (PI3Kγ), with an IC50 of approximately 8 nM. Preclinical studies have demonstrated its anti-inflammatory and antirheumatic properties by inhibiting the progression of joint inflammation and damage in both lymphocyte-independent and -dependent mouse models of rheumatoid arthritis. The compound has been explored primarily as an experimental tool compound for research into inflammatory diseases but has not advanced to clinical development or approval[1][2][7].

Other names

(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dioneCHEBI:45302PI3Kgamma inhibitor IPI-3Kgamma inhibitor IPI 3Kgamma inhibitor I