6-(3-aminophenyl)-N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amine

This compound is a synthetic small molecule belonging to the quinazolinamine class, with the molecular formula C19H19F3N4 and a molecular weight of approximately 360.38 g/mol[1][2][3]. It is primarily characterized as an experimental chemical probe or inhibitor targeting cyclin-dependent kinase 2 (CDK2), a key regulator of cell cycle progression. The compound has demonstrated inhibitory activity against CDK2, with an IC50 value of approximately 600 nM[1][2]. There are no known approved therapeutic indications or clinical uses for this molecule; it is mainly used in research settings to study cell cycle regulation and kinase inhibition.

Other names

6-(3-Aminophenyl)-N-tert-butyl-2-(trifluoromethyl)quinazolin-4-amineN-tert-butyl-2-(trifluoromethyl)-6-(3-aminophenyl)quinazoline-4-amine6-substituted quinazoline 51