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6-(Dihydroxy-Isobutyl)-Thymine

Development stage
Unknown
Modality
Small Molecules
01

Overview

**6-(Dihydroxy-Isobutyl)-Thymine** is a synthetic pyrimidone derivative in which the hydrogen at position 6 of thymine is substituted by a 1,3-dihydroxyisobutyl group. It is classified as an experimental small molecule and has not been approved for clinical use. The compound acts as an inhibitor of cytosolic thymidine kinase, potentially interfering with DNA synthesis or repair by targeting this enzyme. There are no known approved indications or ongoing clinical trials for therapeutic use[1][2][10].

Other names
6-(1,3-dihydroxyisobutyl)thymine6-(Dihydroxyisobutyl)-Thymine6-[3-hydroxy-2-(hydroxymethyl)propyl]-5-methylpyrimidine-2,4(1H,3H)-dione6-[3-hydroxy-2-(hydroxymethyl)propyl]thymine
02

Targets

VVTK (Vaccinia virus thymidine kinase)HSV-TK (Herpes simplex virus type 1 thymidine kinase (HSV1-TK))TK1 (Thymidine kinase 1)

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