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6-amino-benzo[de]isoquinoline-1,3-dione

Development stage: Unknown
Modality: Small Molecules

Overview

6-amino-benzo[de]isoquinoline-1,3-dione is an experimental small molecule belonging to the class of isoquinolones and derivatives. It acts as a potent inhibitor of poly [ADP-ribose] polymerase 1 (PARP1), an enzyme involved in DNA repair processes. The compound has demonstrated inhibitory activity with an IC50 of approximately 22 nM against PARP1. There are currently no approved indications or clinical trials beyond preclinical/experimental stages for this molecule. Its primary mechanism is the inhibition of PARP1, which may have potential applications in oncology and other diseases involving DNA damage response pathways[1].

Other names: 6-amino-benzo[de]isoquinoline-1,3-dione

Targets

PARP1 (Poly (adp-ribose) polymerase 1)

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