6-aza uridine 5'-monophosphate

6-Aza uridine 5'-monophosphate is a synthetic nucleoside monophosphate analogue and the monophosphorylated form of the antimetabolite nucleoside analogue known as 6‑azauridine. It is structurally related to uridine monophosphate but contains a nitrogen atom at position six of the pyrimidine ring (hence "aza"). This compound acts primarily as an inhibitor of orotidine‑5'‑phosphate decarboxylase (EC 4.1.1.23), interfering with de novo pyrimidine biosynthesis and thus inhibiting RNA synthesis in rapidly dividing cells. It has been studied for its antineoplastic properties and as an experimental tool in biochemical research[2][3][4][5]. There are no approved clinical indications.

Other names

6-Azauridine-5'-monophosphate6-aza uridine 5'-monophosphate2018-19-16-Azauridine 5'-phosphoric acid[(2R,3S,4R,5R)-5-(3,5-dioxo-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphateazaUMP