Drug intelligence / Profile preview

6-chlorobenzo[d]isoxazol-3-ol

Development stage: Preclinical
Modality: Small Molecules
Administration: Lateral Ventricle, Oral, Intraperitoneal

Overview

6-chlorobenzo[d]isoxazol-3-ol (CBIO) is a small molecule that functions as an inhibitor of D-amino acid oxidase (DAAO). It has been investigated in preclinical studies for its potential role in mitigating cognitive impairment, such as that induced by arsenic exposure, by modulating D-serine metabolism. Its mechanism involves increasing D-serine levels by preventing its degradation by DAAO.

Other names: 6-chloro-1,2-benzisoxazol-3(2H)-one5-chloro-benzo[d]isoxazol-3-ol

Targets

DAO (D-amino-acid oxidase)

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