6-chloropurine riboside, 5'-monophosphate

**6-Chloropurine riboside, 5'-monophosphate** is a synthetic nucleoside monophosphate analog of adenosine monophosphate (AMP), in which the amino group at position 6 of adenine is replaced by chlorine. It acts as an experimental small molecule and has been studied primarily as a biochemical tool and research compound. Its main mechanism involves inhibition of inosine monophosphate dehydrogenase (IMPDH), an enzyme critical for purine nucleotide biosynthesis. By inhibiting IMPDH—specifically through covalent modification of the enzyme's active site cysteine residue—it disrupts guanine nucleotide synthesis and can exert antiviral and anticancer effects in vitro[4][8]. The compound has not been approved for clinical use but is used experimentally to study purine metabolism and as a potential lead structure for drug development targeting IMPDH[1][8].

Other names

chloropurine riboside-5'-O-monophosphate[(2R,3S,4R,5R)-5-(6-chloropurin-1-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate