6-de-O-sulfated, N-acetylated low-molecular-weight heparin

6-de-O-sulfated, N-acetylated low-molecular-weight heparin (6S-NA-LMWH) is a chemically modified derivative of heparin designed to lack significant anticoagulant activity while retaining the ability to bind and inhibit specific proteins, most notably **Galectin-3 (Gal-3)**. Galectin-3 is a beta-galactoside-binding lectin involved in various pathological processes, including inflammation, fibrosis, and immune cell differentiation. By acting as a competitive inhibitor of Galectin-3, 6S-NA-LMWH has shown therapeutic potential in preclinical models of **IgA nephropathy (IgAN)** and chronic kidney disease. Its mechanism involves the inhibition of the NLRP3 inflammasome, reduction of Th17 cell differentiation, and enhancement of autophagy, which collectively lead to improved renal function and reduced renal lesions and fibrosis.

Other names

6-O-desulfated, N-acetylated heparin6-O-desulfated, N-acetylated LMWH6-de-O-sulfated, N-acetylated heparin