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6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
01

Overview

6‑ethyl‑5‑[(2S)‑1‑(3‑methoxypropyl)‑2‑phenyl‑1,2,3,4-tetrahydroquinolin‑7‑yl]pyrimidine‐2,4‐diamine is a synthetic small molecule belonging to the phenylquinoline class. It features a quinoline moiety substituted with a phenyl group and targets the protein renin. Renin is an aspartic protease involved in the regulation of blood pressure via the renin‐angiotensin system. This compound has been studied as an experimental agent for its potential to inhibit renin activity but does not have any approved clinical indications or known marketed products[1][5][9]. Its primary mechanism of action is presumed to be direct inhibition of renin.

Other names
6-Ethyl-5-[(2s)-1-(3-Methoxypropyl)-2-Phenyl-1,2,3,4-Tetrahydroquinolin-7-Yl]pyrimidine-2,4-Diamine6-Ethyl–5–[(2S)–1–(3-Methoxypropyl)–2–Phenyl–1,2,3,4-Tetrahydroquinolin–7-Yl]pyrimidine–2,4-Diamine
02

Targets

REN (Renin)

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