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6-nitro-2-oxo-2h-chromene-3-sulfonic acid (5-oxo-4,5-dihydro-1h-pyrazol-3-yl)amide
- Development stage
- Preclinical
- Lead developer
- National Research Centre
- Modality
- Small Molecules
01
Overview
6-nitro-2-oxo-2h-chromene-3-sulfonic acid (5-oxo-4,5-dihydro-1h-pyrazol-3-yl)amide is a synthetic sulfonyl coumarin derivative developed as a non-cytotoxic anti-angiogenic agent. Synthesized by researchers at the National Research Centre in Egypt, this small molecule is designed to target pathways involved in tumor angiogenesis without inducing direct cytotoxicity to healthy or cancerous cells. It specifically demonstrates anti-migratory activity against hepatocellular carcinoma (HepG2) cells by inhibiting Matrix Metalloproteinase-2 (MMP-2). Molecular docking studies indicate that the compound fits into the active site of MMP-2, suggesting its potential as a lead compound for targeted molecular therapies in cancer treatment.
- Other names
- 6-nitro-2-oxo-2H-chromene-3-sulfonic acid (5-oxo-4,5-dihydro-1H-pyrazol-3-yl)amide
02
Targets
MMP2 (Matrix metalloproteinase-2)
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