7,10-dimethoxy-10-deacetylbaccatin III

7,10-dimethoxy-10-deacetylbaccatin III is a small molecule taxane derivative that serves as a critical intermediate in the semi-synthesis of cabazitaxel. Developed by XinKe (Xinke Pharma), it is derived from 10-deacetylbaccatin III (10-DAB), a natural compound found in the needles of the *Taxus* species. As a precursor to cabazitaxel, it is essential for the production of therapies targeting advanced, hormone-refractory prostate cancer. The molecule's structure includes specific methoxy groups at the 7 and 10 positions, which are characteristic of the cabazitaxel scaffold, enabling the final drug to bypass certain resistance mechanisms associated with earlier taxanes like docetaxel.

Other names

7,10-dimethoxy-10-DAB III10-deacetyl-7,10-dimethoxybaccatin III