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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Not Applicable (research Chemical)
01
Overview
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is a small molecule chemical compound characterized by a tetrahydroisoquinoline ring system with chlorine substituents at the 7 and 8 positions. It acts as an inhibitor of phenylethanolamine N-methyltransferase (PNMT), an enzyme involved in catecholamine biosynthesis. This compound is used primarily in research related to psychiatric disorders and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It has potential biological activity affecting central nervous system pathways relevant to these conditions[1][2][3]. The compound is for research use only and not approved for direct human use[3][4].
- Other names
- 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
02
Targets
PNMT (Phenylethanolamine N-methyltransferase)
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