7,8-dihydroxy-4-phenyl-2H-chromen-2-one

7,8-dihydroxy‑4‑phenyl‑2H‑chromen‑2-one is a synthetic coumarin derivative and neoflavone (neoflavonoid) with the molecular formula C₁₅H₁₀O₄ and a molecular weight of approximately 254.24 g/mol[6][10][1]. It features hydroxyl groups at positions seven and eight on the chromen ring and a phenyl group at position four. The compound is primarily used as an experimental research tool in phytochemical studies and as a reference standard for natural product analysis[6]. It exhibits antioxidant properties due to its vicinal dihydroxy groups[6], can inhibit Staphylococcus aureus DNA helicase activity[5], and has been reported as an inhibitor of catechol O-methyltransferase (COMT)[2]. There are no approved therapeutic indications or clinical trials beyond preclinical/experimental use.

Other names

7,8-dihydroxy-4-phenylchromen-2-one7,8-Dihydroxy–4–phenylcoumarin4–phenyl–7,8–dihydroxycoumarin4–Phenyl–7,8-dihydroxycoumarine2H–1-Benzopyran–2-one, 7,8-dihydroxy–4-pheny–LDN0063260LDN-0063260LDN 0063260Coumarin 8Coumarin8Coumarin-84-phenyldaphnetin