8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9h-purin-6-ylamine

A synthetic small molecule belonging to the class of purine-based inhibitors. It is structurally related to the purine scaffold and features a dimethoxybenzyl group at position 8, a fluoro substituent at position 2, and a pentyn chain at position 9. This compound is an experimental inhibitor of heat shock protein HSP90-alpha (HSP90AA1), acting on its ATPase activity. Inhibition of HSP90 disrupts its chaperone function required for the stability and function of multiple oncogenic client proteins (such as Raf‑1, CDK4, ErbB2), leading to their degradation and potential anti-cancer effects. The compound has been studied in structural biology contexts but has not advanced into clinical development[7][5][3].

Other names

8-(2,5-dimethoxy-benzyl)-2-fluoro-9-pent-9h-purin-6-ylaMine8-(2,5-dimethoxybenzyl)-2-fluor-9-(4-pentin-1-yl)-9H-purin-6-amIn8-(2,5-dimethoxybenzyl)-2-fluoro-9-(4-pentyn‑1‑yl)‑purin‑6‑amine8-[ (2,5-dimethoxyphenyl)methyl ] -2-fluoro -9 -pent -4 -ynylpurin ‑6 ‑amine