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8-methoxypsoralen + interferon
- Development stage
- Unknown
- Lead developer
- Valeant Pharmaceuticals
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Subcutaneous
01
Overview
This is a combination therapy consisting of 8-methoxypsoralen (also known as methoxsalen or 8-MOP), a photoactive psoralen compound, and an interferon (typically interferon alfa-2a). The regimen is primarily used in conjunction with extracorporeal photochemotherapy (ECP) for the treatment of cutaneous T-cell lymphoma (CTCL), particularly mycosis fungoides. In this protocol, oral 8-methoxypsoralen acts as a photosensitizer; after administration, blood is treated with ultraviolet A (UVA) light outside the body to induce DNA crosslinking and apoptosis in targeted lymphocytes. Interferon alfa-2a is administered subcutaneously to enhance immune modulation and antitumoral effects. This combination has demonstrated improved response rates compared to either agent alone in CTCL stage II patients[1][2]. The mechanism involves both direct cytotoxicity from DNA crosslinking by activated psoralen and immunomodulation via cytokine signaling from interferon.
- Brand names
- Oxsoralen-UltraRoferon-A
- Other names
- 8-MOP + interferonmethoxsalen + interferon8-methoxypsoralen plus interferon alfa-2a
02
Targets
IFNAR (Immune system modulation via type I interferon receptor)ORM1 (Alpha-1-acid glycoprotein 1)DNA
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