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Drug intelligence / Profile preview
8-pCPT-2'-O-Me-cAMP-AM
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
8-pCPT-2'-O-Me-cAMP-AM (also known as 007-AM) is a cell-permeable, selective small molecule activator of the exchange protein directly activated by cyclic AMP (Epac). It is the acetoxymethyl (AM) ester prodrug of 8-pCPT-2'-O-Me-cAMP. Once inside cells, intracellular esterases cleave the AM ester to release the active Epac agonist. 8-pCPT-2'-O-Me-cAMP-AM is highly selective for Epac (primarily Epac1) over protein kinase A (PKA). It is widely utilized as a research reagent to study Epac-mediated signaling pathways, including endothelial junction tightening, insulin secretion in pancreatic beta-cells, and renal protection against ischemia-reperfusion injury. It is not clinically developed or approved for therapeutic use in humans.
- Other names
- 007-AM8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate acetoxymethyl ester8-pCPT-2'-O-Me-cAMP acetoxymethyl ester
02
Targets
EPAC1 (Rap guanine nucleotide exchange factor 3)
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