800-rhNGF + tozuleristide

800-rhNGF + tozuleristide is an investigational intraoperative fluorescence imaging combination developed by Manzanita Pharmaceuticals for use during prostate cancer surgery. The product consists of two distinct fluorescently labeled agents: **800-rhNGF** (recombinant human nerve growth factor conjugated to the near-infrared fluorophore IRDye 800CW) and **tozuleristide** (a chlorotoxin-derived peptide conjugated to indocyanine green, also known as BLZ-100 or 'Cancer Paint'). This dual-agent approach is designed to provide real-time, simultaneous visualization of both the neurovascular bundles (nerves) and the tumor margins during radical prostatectomy. By highlighting the cavernous nerves with 800-rhNGF and the prostate tumor with tozuleristide, the system aims to assist surgeons in maximizing tumor resection while minimizing damage to critical nerves responsible for urinary and sexual function.

Other names

800-rhNGF + BLZ-100rhNGF-IRDye800CW + tozuleristideNerveLight + Cancer Paint