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89Zr-DFO-PSMAi-PEG-Cy5.5-C' dots
- Development stage
- Phase 1
- Lead developer
- Memorial Sloan Kettering Cancer Center
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
89Zr-DFO-PSMAi-PEG-Cy5.5-C' dots is an investigational, dual-modality (PET/optical) silica-based nanoparticle tracer designed for the imaging and surgical guidance of prostate cancer. These nanoparticles, belonging to the Cornell Prime dots (C' dots) platform, are functionalized with a prostate-specific membrane antigen (PSMA) inhibitor (PSMAi) to target tumor cells. The particle surface is coated with polyethylene glycol (PEG) for biocompatibility and incorporates a Cy5.5 fluorescent dye for near-infrared intraoperative optical imaging. Additionally, it features a desferrioxamine (DFO) chelator to bind the positron-emitting radioisotope zirconium-89 (89Zr) for preoperative PET/MRI imaging. This multimodal approach is intended to provide high-resolution localization of cancerous deposits both before and during surgery.
- Other names
- 89Zr-DFO-PSMAi-C' dots89Zr-labeled PSMA-targeting C' dots
02
Targets
PSMA (Prostate-specific membrane antigen)
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