9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine

PU3 (9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amino) is a synthetic small molecule inhibitor of heat shock protein HSP90. It acts by competitively binding to the conserved ATP/ADP pocket of HSP90 (both alpha and beta isoforms), thereby inhibiting its chaperone function. This inhibition leads to the degradation of client proteins such as Her2 and results in growth arrest and differentiation in certain cancer cell lines. PU3 has been shown to induce G1 cell cycle arrest via retinoblastoma protein hypophosphorylation. The compound is primarily used as a research tool for studying HSP90 biology and has not advanced into clinical development or approval for any therapeutic indication[2][5].

Other names

9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amino9-butyl-8-(3,4,5-trimethoxy-benzyl)-9H-purin-6-yamine9-butyl-8-(3,4,5-trimethoxyphenyl)methyl)-9H-purin-6-amino