99mTc-(Na-His)Ac-NT(8-13)

99mTc-(Na-His)Ac-NT(8-13) is a **radiolabeled peptide drug** in which the fragment neurotensin(8–13) is conjugated via a sodium-histidine acetate chelator to technetium-99m. The resulting molecule is primarily used as a molecular imaging agent in single-photon emission computed tomography (SPECT), targeting tumors that overexpress neurotensin receptor 1 (NTS1R). NT(8–13) is an active core of neurotensin—a neuropeptide—and demonstrates high binding affinity to NTS1R, which is notably overexpressed in a variety of human cancers (especially colon adenocarcinoma, as well as pancreatic, prostate, and lung cancers). Upon binding to NTS1R, the radiolabeled compound accumulates in tumor tissues, allowing for non-invasive localization and quantification via SPECT. The presence of the Na-His-Ac chelating group enhances stability and radiolabeling efficiency. The mechanism of action is primarily receptor-mediated uptake by NTS1R-expressing cells, making it a **targeted radiopharmaceutical** for tumor imaging. Developers cited in the literature include academic groups, with no large commercial manufacturer indicated. Clinical application remains principally in research and early-phase clinical studies for oncology imaging[2][5].

Other names

technetium-99m-labeled neurotensin (8-13)99mTc-NT(8-13)technetium-99m neurotensin analogtechnetium99m neurotensin analogtechnetium 99m neurotensin analog