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AB-836 + nucleos(t)ide analogue
- Development stage
- Discontinued
- Lead developer
- Arbutus Biopharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
AB-836 + nucleos(t)ide analogue is a combination therapy containing AB-836, a potent and highly selective hepatitis B virus (HBV) capsid assembly modulator (CAM), together with a nucleos(t)ide analogue, typically standard-of-care agents like entecavir or tenofovir. AB-836 binds to HBV core protein, inhibiting pregenomic RNA (pgRNA) encapsidation and viral replication, as well as interfering with covalently closed circular DNA (cccDNA) formation. The addition of a nucleos(t)ide analogue inhibits the viral polymerase, leading to additive antiviral efficacy. AB-836 demonstrated substantial reductions in HBV DNA levels in clinical studies but was discontinued due to safety findings. The combination represents a mechanistically complementary approach for disrupting HBV replication and cccDNA establishment.
- Other names
- AB-836 + NA
02
Targets
HBV Pol (Hepatitis B virus polymerase)HBc (Hepatitis B virus core protein)
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