abacavir + amprenavir

**Abacavir + amprenavir** is an oral combination of two **antiretroviral drugs** used in the treatment of **HIV-1 infection**. - **Abacavir** is a nucleoside reverse transcriptase inhibitor (NRTI), which inhibits the viral enzyme reverse transcriptase, thereby blocking viral DNA synthesis and replication[1][3][7]. - **Amprenavir** is a protease inhibitor (PI) that inhibits the HIV-1 protease enzyme, preventing the cleavage of viral polyprotein precursors, which blocks the formation of mature, infectious virus particles[2][4]. This combination targets two distinct steps in the HIV replication cycle, offering a potent antiviral effect. This drug combination is not co-formulated under a unique brand name; it is instead a concomitant use of the two agents. It is not marketed as a fixed-dose combination.