abacavir + saquinavir

Abacavir + saquinavir is a combination of two antiretroviral drugs used in the treatment of HIV infection. Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) that acts as a guanosine analog, interfering with the action of HIV-1 reverse transcriptase and terminating viral DNA chain elongation. Saquinavir is a protease inhibitor that prevents the cleavage of viral polyproteins by HIV-1 protease, resulting in immature, noninfectious viral particles. Both agents are used as part of combination antiretroviral therapy but are not typically co-formulated or branded together, and co-administration must be monitored closely due to individual pharmacokinetics and potential drug-drug interactions[1][2][4][6].

Brand names

Invirase (for saquinavir)Fortovase (for saquinavir)

Other names

abacavir + saquinavir