abatacept + mycophenolate mofetil + corticosteroids

This is a **combination therapy** consisting of abatacept (a selective T-cell co-stimulation modulator and fusion protein blocking CD80/CD86 on antigen-presenting cells), mycophenolate mofetil (a small molecule prodrug inhibiting inosine monophosphate dehydrogenase, thus suppressing lymphocyte proliferation), and corticosteroids (a class of steroid hormones with potent anti-inflammatory and immunosuppressive effects). The regimen is an aggressive immunosuppressive approach used in refractory autoimmune and inflammatory conditions (such as juvenile dermatomyositis, lupus nephritis, or immune checkpoint inhibitor-induced inflammatory conditions) when conventional therapy fails. Each component works through a distinct mechanism to synergistically suppress immune activity, targeting T cell activation, lymphocyte proliferation, and broad inflammatory responses[1][2][3][6].

Brand names

Orencia + Cellcept + corticosteroids

Other names

ABA + MMF + corticosteroids