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ABBV-623 + ABBV-992

Development stage: Discontinued
Lead developer: AbbVie
Modality: Small Molecules
Administration: Oral

Overview

ABBV-623 + ABBV-992 is an investigational oral combination therapy developed by AbbVie for the treatment of B-cell malignancies, including B-cell cancers such as chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and other hematological malignancies. ABBV-623 is a small molecule inhibitor of B-cell lymphoma-2 (BCL2), targeting the anti-apoptotic proto-oncogene protein c-bcl-2 to induce apoptosis in malignant B cells. ABBV-992 is also a small molecule, though its precise molecular target is not publicly specified; it is being evaluated in clinical studies together with ABBV-623 for its potential synergistic effect in targeting B-cell cancer pathways. The combination is administered as oral tablets and was studied in Phase 1 trials for safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy in subjects with B-cell malignancies.

Other names: ABBV-623 + ABBV-992

Targets

BCL-2 (BCL-2 family)

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