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ABI-1179 + ABI-5366
- Development stage
- Unknown
- Lead developer
- Gilead Sciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ABI-1179 and ABI-5366 are novel, long-acting small molecule inhibitors of the viral helicase-primase enzyme complex, which is essential for the replication of herpes simplex virus (HSV). Developed through a collaboration between Assembly Biosciences and Gilead Sciences, with historical licensing roots involving Medivir, these compounds are designed to improve chronic suppressive therapy for recurrent genital herpes (HSV-2). Both assets are currently in Phase 1b clinical trials and have demonstrated pharmacokinetic profiles supportive of once-weekly oral dosing, potentially offering a significant improvement over current daily antiviral therapies by providing sustained viral suppression and improved clinical outcomes.
- Other names
- HSV helicase-primase inhibitor program
02
Targets
Herpes simplex virus type 2 helicase-primase complex (UL5/UL52/UL8)
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