Drug intelligence / Profile preview

abiraterone decanoate (Astellas Pharma)

Development stage
Unknown
Lead developer
Astellas Pharma
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intramuscular
01

Overview

Abiraterone decanoate is a long-acting prodrug of abiraterone, designed for intramuscular (IM) depot administration. It provides controlled release of abiraterone, a potent inhibitor of steroid 17-alpha-hydroxylase (CYP17), which is essential for androgen biosynthesis. By inhibiting CYP17, it suppresses the production of testosterone and other androgens that can drive the growth of prostate cancer cells. Abiraterone decanoate is being developed primarily for advanced or metastatic prostate cancer as an alternative to daily oral abiraterone acetate, aiming to improve pharmacokinetics and patient compliance by reducing dosing frequency and potentially minimizing peak-related toxicities. The drug is under investigation in clinical trials for advanced prostate cancer[2][3][4][5][6].

Other names
abiraterone decanoate
02

Targets

CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)

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